When Medications are Prescribed for T2D Management


When you’re newly diagnosed with Type 2 diabetes, you may be wondering if or when you’ll need medication to manage it and which medications are available to you. Fortunately, there’s a protocol listed in the American Diabetes Association’s 2021 Standards of Care that healthcare professionals follow to determine when and what kinds of medications are recommended to help you reach your glycemic goals. In this article, we’ll list the drugs indicated for Type 2 diabetes management, as well as when and how doctors are guided towards making the choice to recommend them to patients.

Medications for Type 2 Diabetes Management

  • Metformin (Biguanides)
  • Basal Insulin (Long-acting insulin)
  • Bolus Insulin (Mealtime/rapid-acting/prandial insulin)
  • Mixed Insulin
  • Sulfonylureas
  • Thiazolidinediones (TZDs)
  • Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
  • Sodium-Glucose Cotransporter 2 (SGLT-2) Inhibitors
  • Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists
  • Glucagon

How Doctors Determine When to Prescribe Medication


The first line of treatment for Type 2 diabetes is with metformin, along with lifestyle modifications. Although metformin’s side effects include gastrointestinal issues such as bloating, abdominal discomfort, and diarrhea, this drug is safe and inexpensive and the side effects can be lessened when metformin is taken gradually.

Combination Therapy

It’s important to remember that Type 2 diabetes is a progressive chronic illness, so the treatment with metformin may only work for a few years until another medication is added, at no fault of the patient. Combination therapy allows for patients to reach their A1C targets and sustain their progress.

When A1C is 1.5 percent or more above target, most patients will require some sort of combination therapy, in other words, taking metformin with another medication. In this case, a doctor may prescribe insulin in patients with glucose levels at or above 300 mg/dL (16.7 mmol/L) or an A1C above 10 percent (86 mmol/mol), or if the patient is experiencing hyperglycemic symptoms such as polyuria and polydipsia (frequent urination or thirst) or weight loss. Doctors may also recommend a sulfonylurea.

The Standards of Care advises healthcare professionals not to delay discussing the combination therapy strategy when treatment goals aren’t being met. The choice of intensifying treatment depends on the preferences of the patient and the progress of their diabetes management, including other health and socioeconomic factors such as:

  • Cardiovascular diseases
  • Chronic kidney disease
  • Other comorbidities
  • Cost
  • Potential side effects, safety, and tolerability

Also, if a patient isn’t reaching their target goals within three months, metformin can be combined with any of these six treatments:

  • Sulfonylureas
  • Basal Insulin
  • TZDs
  • DPP-4s
  • SGLT-2s
  • GLP-1 RAs

When Medications are Prescribed for Patients with Type 2 Diabetes and Cardiovascular Disease or Chronic Kidney Disease

For patients who are 55 years old or older who have or at high-risk for cardiovascular diseases (CVD) and chronic kidney disease (CKD), an SGLT-2 or a GLP-1 is recommended independently of A1C or metformin use. These drugs have displayed benefits for patients with CVD and CKD.

For patients who aren’t at risk or have a history of CVD or CKD, the decision to add a second (or third) drug to the treatment with metformin is based on efficacy, avoidance of side effects such as hypoglycemia and weight gain, cost, and the patient’s preferences.

How Insulin is Prescribed

Unfortunately, people within the Type 2 diabetes community have been threatened with the prescription of insulin or see the start of insulin therapy as a sign of failure of managing diabetes. But, insulin therapy is an effective way to manage Type 2 diabetes and the start of it is never the patient’s fault, but just a sign of T2D progression. With that said, it’s important for healthcare professionals to continually explain the progression of Type 2 diabetes.

The kinds of insulins available are:

  • Basal (long-acting) insulin
  • Bolus (meal-time or rapid-acting) insulin
  • Concentrated Insulin
  • Inhaled Insulin

Basal Insulin: 

Basal insulin regulates glucose overnight and between meals and lasts for 24 hours. This kind of insulin can be added to metformin or used alone. Starting doses are estimated based on body weight, the intensity of hyperglycemia, and trial and error based on the patient’s experiences.

Mealtime Insulin: 

Mealtime insulin, also called rapid-acting or prandial insulin, are taken before meals and in addition to basal insulin. To start, a doctor may recommend a dose of 4 units or 10 percent of the amount of basal insulin and adjust it according to the patient’s needs. Mealtime insulin acts within 15-20 minutes and peaks around 2-4 hours after injections.

Concentrated Insulin: 

Concentrated insulins deliver larger doses of insulin with less volume per milliliter and decrease the number of injections needed at one time for those who need higher doses of insulin. For example, a U-200 insulin pen only requires half the dose of a U-100 pen because it’s twice as concentrated as U-100 insulin. Concentrated insulin pens come in U-200, U-300, and U-500 pens.

Inhaled Insulin: 

Inhaled insulin is used right before or during a meal or used to correct high blood sugar. Its effects are felt rapidly, but this type of insulin is contraindicated in people with lung disease, asthma, and pulmonary disease. It’s also not recommended in those who smoke or recently ceased smoking. Patients must take a spirometry test, a test that determines how well your lungs work, before and after starting the use of inhaled insulin therapy.

Can Insulin Be Used with Other Medications? 

Yes. Insulin can be combined with other medications. If basal insulin is having a positive impact on fasting glucose but A1C remains above target, then another type of injectable such as a GLP-1 is recommended.

Also, when starting combination injection therapy, the Standards of Care recommend the treatment of metformin continue and the use of SFUs and DPP-4 inhibitors are gradually discontinued. TZDs and SGLT-2 inhibitors may help those improve management and reduce the amount of insulin needed in those who are having trouble manage diabetes, even with large doses of insulin.

Finally, as adults with Type 2 diabetes get older, it’s important to simplify complex insulin regimens because of a decreased ability in self-management.


It’s also important to know if you’re being prescribed insulin or any other kind of diabetes medication, your risk of experiencing low blood sugarhypoglycemia increases. To stay prepared for low blood sugar episodes, your healthcare provider may advise you to keep a snack or fast-acting carbs on hand and provide a prescription for glucagon, a medication that raises your blood sugar to normal levels, for emergency situations. Traditional glucagon kits contain a syringe, however, nasal glucagon is a non-injectable, dry nasal spray. Nasal glucagon also doesn’t need to be inhaled, therefore, if a patient loses consciousness due to severely low blood sugar, this treatment can be administered.

What Should I Ask My Doctor?

If you’re considering different medications to help you manage Type 2 diabetes, make sure to speak with your doctor about which medications are best for you and your situation. Take into account the following factors:

  • Safety and side effects, including hypoglycemia
  • Obtaining a prescription for nasal glucagon
  • Benefits or risks for other health-related issues
  • Frequency of dosing
  • Cost

Check out our Type 2 guides on oral medications and insulin for more information on how they help with Type 2 diabetes management.

Key Takeaways on When Medications are Prescribed:

  • Metformin is the first line of treatment at diagnosis.
  • Because Type 2 diabetes is a progressive chronic illness, metformin may work for few years until another kind of medication is recommended, called combination therapy.
  • Combination therapy helps patients reach and sustain their glycemic goals.
  • Some medications are recommended because they benefit people at high risk of chronic kidney disease and cardiovascular disease.
  • Insulin, such as basal (long-acting) insulin, is recommended due to T2D progression, at no fault of the patient. Other insulins available are bolus (meal-time) insulin, concentrated insulin, and inhaled insulin.
  • Insulin can be combined with other medications such as a GLP-1 if A1C targets no fault of the patient.
  • Remember, the use of medication is never the patient’s fault and should never be used as a threat by healthcare providers.

WRITTEN BY T'ara Smith, MS, Nutrition Education, POSTED 01/29/21, UPDATED 05/10/21

T’ara was diagnosed with Type 2 diabetes in July 2017 at the age of 25. Since her diagnosis, she focused her academic studies and career on diabetes awareness and living a full life with it. She’s excited to have joined the Beyond Type 1 team to continue her work. Two years later, T'ara discovered she'd been misdiagnosed with Type 2 and actually has LADA. Outside the office, T’ara enjoys going to the movies, visiting parks with her dog, listening to BTS, and cooking awesome healthy meals. T’ara holds an MS in Nutrition Education from American University.